ole of IL - 1 in Poststroke Depressive - like Behavior n Mice ara

ackground: Poststroke depression (PSD) leads to impaired functional recovery and increased mortality, yet physiological echanisms are unknown. The present study investigates the roles of glucocorticoids and interleukin-1 (IL-1) in poststroke anhedonia. ethods: Adult male mice underwent middle cerebral artery occlusion (MCAO), and were recovered 7 days. Mice were treated with etyrapone (100 mg/kg intraperitoneally), mifepristone (50 mg/kg subcutaneously), or vehicle injections on reperfusion days 4–7. A eparate cohort of mice was implanted with cannulae and was administered IL-1 receptor antagonist (IL-1ra) or vehicle (6 g ntracerebroventricularly) on reperfusion days 6 and 7. After the final injection or infusion, sucrose consumption was recorded for hours. esults: Mice in the sham-treated group consumed significantly more sucrose solution than water, whereas MCAO-treated mice onsumed similar amounts of each, suggesting anhedonia among MCAO-treated mice. A separate experiment assessed whether troke-induced increases in corticosteroids or IL-1 contribute to anhedonia. Only IL-1ra restored sucrose consumption in MCAOreated mice. Vehicle-MCAO–treated mice drank significantly less sucrose solution than did both IL-1ra and vehicle-sham treatment roups, whereas IL-1ra–MCAO-treated mice drank similar amounts to both sham-treated groups. onclusions: Poststroke anhedonia, a symptom of depression in human beings, can be reproduced in a mouse model of stroke and ppears to involve altered IL-1 transmission in the brain.